Objective To investigate the effect of debridement and cosmetic suture for soft tissue trauma of head and face skin. Methods A total of 108 patients with head and face skin tissue trauma admitted to our hospital from January to November 2020 were selected as observation subjects. They were divided into routine group and study group by digital random table method, with 54 cases in each group. The conventional group was treated with debridement and conventional suture, and the study group was treated with debridement and cosmetic suture. The total effective rate, treatment satisfaction, treatment cost, wound healing time, VSS scar score, VAS pain score and incidence of adverse reactions were compared between the two groups. Results The total effective rate and treatment satisfaction of the study group were higher than those of the conventional group (P＜0.05). The treatment cost of the study group was higher than that of the conventional group, and the wound healing time was shorter than that of the conventional group, meanwhile the VSS scar score, VAS pain score and incidence of adverse reactions were significantly lower than those of the conventional group (P＜0.05). Conclusion Compared with conventional debridement suture, cosmetic suture has the advantages with light scar, light pain, rapid wound healing, less adverse reactions and high safety.