Objective To analyze the clinical effect of sodium hyaluronate combined with anti-inflammatory drugs in the treatment of trachoma-induced xerophthalmia. Methods A total of 76 patients with trachoma-induced xerophthalmia treated from January 2020 to July 2021 in Yanchang County Hospital of Traditional Chinese Medicine were selected as research subjects. According to random number table, patients were divided into control group and study group, with 38 cases in each group. The control group was treated with sodium hyaluronate, the study group was treated with sodium hyaluronate and anti-inflammatory drugs. Therapeutic effects, lacrimal secretion, tear film break-up time and corneal topography parameters were compared. Results The total effective rate of the study group was 92.11%, which was higher than 76.32% of the control group, and the difference was statistically significant (P<0.05). The SchirmerⅠ test results and BUT of the study group were higher than those of the control group after treatment, and the difference was statistically significant (P<0.05). SRI and SAI in the study group were lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion The combination of sodium hyaluronate and anti-inflammatory drugs has positive significance in the treatment of patients with trachoma-induced xerophthalmia is of positive significance, which can effectively improve the symptoms of ocular dryness and delay the secretion of lacrimal gland. The clinical effect is accurate and has promotional value.