Objective To explore the clinical effect of medical cotton cloth nursing patch combined with dehumidification mixture in the treatment of facial dermatitis. Methods A total of 88 patients with facial dermatitis who were treated in the outpatient department of Pizhou Hospital of Traditional Chinese Medicine from January 2021 to June 2022 were selected as the study subjects. They were divided into the observation group and the control group according to the random number table method, with 44 patients in each group. The control group was treated with dehumidification mixture, and the observation group was treated with medical cotton cloth nursing patch adjuvant combined with dehumidification mixture. The treatment effectiveness, skin erythema area and transdermal water loss, and symptom score were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group (P