Objective To explore the application effect of refined nursing in the treatment of acne patients with glycolic acid peels. Methods From May 2021 to May 2022, 200 patients with acne treated by glycolic acid peels in our hospital were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 100 cases in each group. The control group was given routine nursing, and the observation group was given refined nursing. The psychological status, compliance, quality of life and satisfaction of the two groups were compared. Results The SAS and SDS scores of the observation group after nursing were lower than those of the control group, and the differences were statistically significant (P