Objective To observe the effect of targeted nursing of perioperative pressure sore in patients with intracranial aneurysm rupture hemorrhage treated by interventional embolization. Methods Sixty patients with ruptured intracranial aneurysms treated by interventional embolization in the First Affiliated Hospital of Anhui Medical University from March 2020 to April 2021 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 30 cases in each group. The control group received routine nursing, and the observation group received targeted nursing of perioperative pressure ulcer on the basis of the control group. The incidence of pressure ulcers, quality of life and nursing satisfaction were compared between the two groups. Results The incidence of pressure ulcer in the observation group was 3.33%, which was higher than 23.33% in the control group, the difference was statistically significant (P