Objective To analyze the application effect of music nursing in patients undergoing local anesthesia in plastic surgery. Methods A total of 108 patients undergoing plastic surgery under local anesthesia admitted to the Department of Medical Cosmetology of BenQ Medcial Center in Nanjing from December 2019 to December 2021 were selected as the research objects. According to the random number table method, they were divided into experimental group and control group, with 54 cases in each group. The control group was given routine nursing, and the experimental group was given routine nursing+music nursing. The perioperative related indicators, satisfaction, psychological status and pain degree were compared between the two groups. Results The intraoperative and postoperative VAS scores of the experimental group were lower than those of the control group (P