Objective To explore the effect of integrated hospital infection prevention and control model in hospital infection management. Methods A self-control study was conducted to compare the effects of the traditional hospital infection prevention and control model and the integrated hospital infection prevention and control model of medical care. The monitoring contents were evaluated from six aspects, including hand hygiene, medical waste, disinfection and isolation, multi-drug resistant bacteria, occupational exposure and infectious diseases. Results The correct rate of medical waste treatment, the correct rate of disinfection and isolation knowledge, the correct rate of occupational exposure knowledge, and the correct rate of infectious disease monitoring in integrated hospital infection prevention and control model were higher than those in the traditional hospital infection prevention and control model (P<0.05). Although there were fluctuations in the correct rate of hand hygiene execution and multi-drug resistant bacteria infection, integrated hospital infection prevention and control model was still better than the traditional mode (P<0.05). After the implementation of the integrated medical and nursing infection control mode, the comprehensive level of hospital infection control in the department increased from 34th to 3rd. Conclusion The implementation of the integrated hospital infection prevention and control model has effectively controlled the incidence of hospital infection, greatly increased the hand hygiene compliance rate of medical staff and the pathogenic detection rate related to hospital infection diagnosis. It is an effective and feasible hospital infection prevention and control model.