At present, minimally invasive therapies such as injections and photoelectricity have become popular medical aesthetic items because of their good results in anti-aging and short recovery time. Soft tissue fillers have been used for tissue augmentation for more than 20 years, and there are several soft tissue fillers to choose from, such as non-animal, stabilized hyaluronic acid (NASHA), calcium hydroxyapatite (microcrystalline porcelain) and poly-L-lactic acid (PLLA) fillers, there are some differences in the efficacy of different fillers. On the basis of reading relevant literature, this article reviews the differences between Ellansé? and and hyaluronic acid cosmetic injection, in order to provide some reference value for the selection of clinical medical aesthetic filler materials