Objective To explore the application effect of standardized nursing in patients with cerebral infarction and its influence on quality of life. Methods A total of 68 patients with cerebral infarction admitted to Mengyin County People's Hospital from February to October 2022 were selected as the research objects. They were divided into control group and study group by random number table method, with 34 cases in each group. The control group was given routine nursing, and the study group was given standardized nursing on the basis of the control group. The rehabilitation effect, limb function [limb motor function (FMA) score, functional ambulation category (FAC) score, daily living ability index (MBI) score, Berg balance scale (BBC) score], quality of life and nursing satisfaction were compared between the two groups. Results The total effective rate of rehabilitation in the study group was 94.12%, which was higher than 64.71% in the control group (P