Objective To investigate the clinical effect of small incision liposuction and continuous embedding double eyelid plasty in patients with asymmetric double eyelid. Methods Forty patients with asymmetric double eyelids admitted to our hospital from May 2020 to May 2022 were selected as the research objects. They were divided into conventional group and study group by random number table method, with 20 cases in each group. The conventional group was treated with incision double eyelid plasty, the study group was treated with small incision liposuction and continuous embedding double eyelid plasty. The clinical efficacy, clinical indicators, complications and treatment satisfaction were compared between the two groups. Results The total effective rate of treatment in the study group was 100.00%, which was higher than 75.00% in the conventional group (P <0.05). The operation time and incision healing time of the study group were shorter than those of the conventional group, and the intraoperative blood loss was less than that of the conventional group (P <0.05). The incidence of complications in the study group was 5.00%, which was lower than 35.00% in the conventional group (P <0.05). The treatment satisfaction of the study group was 95.00%, which was higher than 75.00% of the conventional group (P <0.05). Conclusion Small incision liposuction and continuous embedding double eyelid plasty for patients with asymmetric double eyelid can not only achieve ideal therapeutic effect, but also correct the double eyelids and make them symmetrical. Meanwhile, it can shorten the operation time and promote the healing of the incision, the intraoperative blood loss is smaller, the risk of postoperative complications is lower, and the patient's satisfaction with the treatment is higher.