Objective To compare the clinical effect of metal-ceramic crown and all-ceramic crown in repairing anterior teeth defect. Methods A total of 80 patients with anterior teeth defect admitted to our hospital from November 2019 to October 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 40 cases in each group. The control group was repaired with metal-ceramic crown, and the observation group was repaired with all-ceramic crown. The repair effect, oral health-related quality of life and inflammatory factor levels were compared between the two groups. Results The marginal fitness, restoration retention, secondary caries, gingival status and restoration shape scores of the two groups after repair were higher than those before repair, and those in the observation group were higher than those in the control group, the difference was statistically significant (P <0.05). The scores of positive feelings, chewing ability, overall health and aesthetics of the two groups after repair were higher than those before repair, and those in the observation group were higher than those in the control group, the difference was statistically significant (P <0.05). The levels of TNF-α, ALP and IL-6 in gingival crevicular fluid of two groups after repair were lower than those before repair, and those in the observation group were lower than those in the control group, the differences were statistically significant (P <0.05). Conclusion The effect of all-ceramic crown in repairing anterior teeth defect is better than that of metal-ceramic crown, which can improve the oral health-related quality of life of patients, actively inhibit the level of inflammatory factors and promote oral health.