Objective To explore the application effect of path health education management combined with childlike nursing program in the nursing of children with Henoch-Sch?nlein purpura. Methods Thirty children with Henoch-Sch?nlein purpura admitted to our hospital from September 2021 to December 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 15 cases in each group. The control group was given routine nursing program, while the observation group was given path health education management combined with childlike care program. The psychological state, compliance, quality of life and nursing satisfaction of the two groups were compared. Results After intervention, the scores of school terror, generalized anxiety, separation anxiety, social terror and somatic terror in the observation group were lower than those in the control group, and the differences were statistically significant (P <0.05). The compliance of the observation group was higher than that of the control group, and the difference was statistically significant (P <0.05). The scores of social function, emotional function, physiological function and role function in the observation group were higher than those in the control group, and the differences were statistically significant (P <0.05). The nursing satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P <0.05). Conclusion The application of path health education management and childlike nursing program in children with Henoch-Sch?nlein purpura is effective, which can alleviate the negative emotions of children, improve the compliance of children, improve the quality of life and nursing satisfaction, and is worthy of clinical application.