Objective To explore the application value of refined nursing intervention in chloasma patient treated with glycolic acid peels. Methods A total of 28 patients with chloasma treated with glycolic acid peels in our hospital from January 2021 to January 2023 were selected as the research objects and randomly divided into control group and observation group, with 14 patients in each group. The control group was given routine nursing, and the observation group was given refined nursing. The nursing effect, nursing satisfaction and quality of life were compared between the two groups. Results The total effective rate of nursing in the observation group was higher than that in the control group, but the difference was not statistically significant ( P >0.05). The quality of life score of the observation group after intervention was higher than that of the control group ( P <0.05). The nursing satisfaction of the observation group was higher than that of the control group ( P <0.05). Conclusion The application of refined nursing intervention in chloasma patient treated with glycolic acid peels is effective, which can improve the quality of life, with high patients' satisfaction, and is worthy of clinical application.