Objective To investigate the application effect of compound Muniziqi granules combined with tranexamic acid and centella triterpenes cream in female patients with chloasma. Method A total of 116 female chloasma patients admitted to our hospital from January 2017 to December 2019 were selected as the research objects and divided into control group and experimental group according to the random number table method, with 58 patients in each group. The experimental group was given compound muniziqi granules+tranexamic acid+centella triterpenes cream, while the control group was given tranexamic acid tablets+centella triterpenes cream. The clinical efficacy and quality of life of the two groups were compared. Results The total effective rate of the experimental group was 93.10%, which was higher than 79.31% of the control group ( P <0.05). The quality of life score of the experimental group was higher than that of the control group ( P <0.05). Conclusion Compound Muniziqi granule combined with tranexamic acid tablets and centella triterpenes cream is effective and safe in the treatment of chloasma, which can improve the quality of life of patients and is worthy of clinical application.