Objective To explore the effect of recombinant humanized collagen nasal mucosa repair dressing on the recovery of nasal mucosa after endoscopic sinus surgery. Methods A total of 78 patients with sinusitis who underwent endoscopic sinus surgery in our hospital from August 2022 to February 2023 were selected as the research objects. According to the different postoperative intervention schemes, they were divided into control group ( n =39) and observation group ( n =39). The control group was given normal saline to wash the nasal cavity and mometasone furoate nasal spray. The observation group was given recombinant humanized collagen nasal mucosal repair dressing on the basis of the control group. The nasal mucosal function (nasal mucociliary clearance rate, nasal mucociliary clearance rate), mucosal wound cleaning time, nasal mucosal outcome and adverse reactions were compared between the two groups before and 4 weeks after operation. Results The nasal mucus cilia clearance rate and nasal mucus clearance rate in the observation group were higher than those in the control group at 4 weeks after operation, and the differences were statistically significant ( P <0.05). The postoperative wound cleaning time of the observation group was shorter than that of the control group, and the difference was statistically significant ( P <0.05). There was no significant difference in the incidence of postoperative nasal bleeding, nasal mucosal edema, vesicles, adhesions and scar hyperplasia between the two groups ( P >0.05). No adverse reactions occurred in both groups. Conclusion Recombinant humanized collagen nasal mucosal repair dressing has a strong promoting effect on the recovery of nasal mucosal function after endoscopic sinus surgery, and can shorten the postoperative recovery time of patients. It is safe and worthy of clinical application.