Objective To analyze the cognition and demand for medical beauty among permanent residents in northern Guangdong, and analyze its influencing factors. Methods A questionnaire survey was conducted to investigate the awareness and demand for medical beauty among the permanent population in northern Guangdongfrom June to July 2022. Results Of 25.85% (38/147) of the permanent population in northern Guangdong had received medical beauty programs and 69.62% (55/79) of the population with medical beauty programs in the next five years. Binary Logistic regression analysis showed that gender, education, medical and cosmetic experience and cosmetic psychological status were the influencing factors of the demand for medical beauty ( P <0.05). Conclusion The permanent residents in northern Guangdong have a higher acceptance of medical beauty and a more rational consumption view.