Objective To evaluate the curative e?ect of Kangfuxin liquid combined with vitamine C and Beifuji in the Treatment of oral ulcers. Methods Sixty patients with oral ulcers admitted to People’s Hospital of Anshun City from August 2021 to August 2022 were randomly divided into conventional group (given Kangfuxin liquid treatment, n=30) and study group (given Kangfuxin liquid combined with vitamin C and Beifuji treatment, n=30). The ulcer surface healing, clinical efcacy, pain relief time and VAS score were compared between the two groups. Results The healing time of ulcer surface in the study group was shorter than that in the conventional group (P<0.05). The total e?ective rate of treatment in the study group was 96.67%, which was higher than 70.00% in the conventional group (P<0.05). The pain relief time of the study group was shorter than that of the conventional group (P<0.05). After treatment, the VAS score of the study group was lower than that of the conventional group (P<0.05). Conclusion For patients with oral ulcer, compared with Kangfuxin liquid treatment alone, Kangfuxin liquid combined with vitamin C and Beifuji is more e?ective, which can e?ectively shorten the healing time of ulcer surface and pain relief time, and relieve the pain of patients.