Objective To explore the e?ect of MEBO in preventing striae gravidarum. Methods A total of 100 pregnant women who were hospitalized in the First People 's Hospital of Zunyi from September 2021 to September 2022 were selected and divided into control group and observation group by random number table method, with 50 pregnant women in each group. The control group used warm water to scrub the abdomen and then applied glycerin to give routine nursing; the observation group was smeared with MEBO after scrubbing the abdomen with warm water, and given high-quality nursing. The prevention e?ect, striae gravidarum severity, psychological state and nursing satisfaction were compared between the two groups. Results The total e?ective rate of the observation group was 94.00%, which was higher than 74.00% of the control group (P<0.05). The severity of striae gravidarum in the observation group was lower than that in the control group at the 4th, 8th and 12th week. (P<0.05). The scores of anxiety and depression in the observation group were lower than those in the control group (P<0.05). The nursing satisfaction of the observation group was 94.00%, which was higher than 78.00% of the control group (P<0.05). Conclusion The application e?ect of MEBO and high quality nursing in the prevention of striae gravidarum is ideal, which can improve the satisfaction of pregnant women, improve negative emotions, and have good application value.