外用碱性成纤维细胞生长因子凝胶联合超脉冲CO2点阵激光治疗痤疮瘢痕的效果
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丛纲(1978.7-),男,江苏南通人,硕士,副主任医师,主要从事整形外科方面研究

通讯作者:

袁建飞(1975.2-),女,江苏南通人,本科,主治医师,主要从事美容皮肤科方面研究

中图分类号:

R758.73+3; R619+.6

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Effect of Recombinant Human Basic Fibroblast Growth Factor Combined with Ultrapulsed CO2 Fractional Laser in the Treatment of Acne Scars
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    摘要:

    探讨给予痤疮瘢痕患者重组人碱性成纤维细胞生长因子(rh-bFGF)联合超脉冲CO2 点阵激光治疗的效果。方法 选取2020年1月-2021年12月我院收治的80例痤疮瘢痕患者为研究对象, 以随机数字表法分为对照组和观察组,各40例。对照组接受超脉冲CO2点阵激光治疗,观察组接受rhbFGF 联合超脉冲CO2点阵激光治疗,比较两组临床疗效、症状改善情况、瘢痕情况及血清炎性因子水 平。结果 观察组治疗总有效率为95.00%,高于对照组的72.50%(P <0.05);观察组水肿消退时间、结痂 时间、红斑持续时间均短于对照组,VAS评分低于对照组(P <0.05);观察组治疗后VSS评分低于对照 组(P <0.05);观察组治疗后IL-10、IL-17、TNF-α水平均低于对照组(P <0.05)。结论 rh-bFGF 联合超脉冲CO2点阵激光治疗痤疮瘢痕的效果理想,可有效调控局部炎性因子,改善瘢痕情况,促进 症状消失。

    Abstract:

    To investigate the effect of recombinant human basic fibroblast growth factor (rh-bFGF) combined with ultra-pulsed CO2 fractional laser in the treatment of acne scars. Methods A total of 80 patients with acne scars admitted to our hospital from January 2020 to December 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 40 patients in each group. The control group was treated with ultrapulsed CO2 fractional laser, and the observation group was treated with rh-bFGF combined with ultra-pulsed CO2 fractional laser. The clinical efficacy, symptom improvement, scar condition and serum inflammatory factor levels were compared between the two groups. Results The total effective rate of treatment in the observation group was 95.00%, which was higher than 72.50% in the control group (P <0.05). The edema regression time, crusting time and erythema duration in the observation group were shorter than those in the control group, and the VAS score was lower than that in the control group (P <0.05). After treatment, the VSS score of the observation group was lower than that of the control group (P <0.05). After treatment, the levels of IL-10, IL-17 and TNF-α in the observation group were lower than those in the control group (P <0.05). Conclusion The effect of rh-bFGF combined with ultrapulsed CO2 fractional laser in the treatment of acne scars is ideal, which can effectively regulate local inflammatory factors, improve scar conditions, and promote the disappearance of symptoms.

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丛纲,袁建飞.外用碱性成纤维细胞生长因子凝胶联合超脉冲CO2点阵激光治疗痤疮瘢痕的效果[J].医学美学美容,2023,32(20):63-66.

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  • 在线发布日期: 2023-11-30
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