To analyze the application effect of psychological nursing combined with health education in patients with burn and plastic surgery. Methods A total of 72 patients who underwent burn and plastic surgery in our hospital from January 2022 to March 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 36 patients in each group. The control group was treated with routine nursing, and the observation group was treated with psychological nursing combined with health education. The psychological status, quality of life and nursing satisfaction of the two groups were compared. Results The HAMA score and HAMD score of the observation group after nursing were lower than those of the control group (P <0.05). The scores of physical function, social function, material life and psychological function in the observation group were higher than those in the control group (P <0.05). The nursing satisfaction of the observation group was 94.44%, which was higher than 77.78% of the control group (P <0.05). Conclusion Psychological nursing combined with health education is effective in patients with burn and plastic surgery, which can effectively improve the psychological state of patients, improve their quality of life, and patients' satisfaction with nursing services is high.