To analyze the clinical effect of orthodontics combined with periodontal basic treatment in patients with anterior teeth displacement caused by periodontal disease. Methods Sixty patients with anterior tooth displacement caused by periodontal disease admitted to the Affiliated Stomatological Hospital of Suzhou Vocational Health College from November 2020 to November 2021 were selected as the research objects. They were divided into observation group and control group according to the random number table method, with 30 patients in each group. The observation group was treated with orthodontics combined with periodontal basic treatment, and the control group was treated with periodontal basic treatment. The functional indexes of anterior teeth, the levels of inflammatory factors and clinical effects were compared between the two groups. Results After treatment, the deep overbite of anterior teeth, the deep overbite distance of anterior teeth and the height of alveolar bone in the two groups were better than those before treatment, and those in the observation group were better than the control group (P <0.05). After treatment, the levels of TNF-α, IL-6 and IL-8 in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P <0.05). The total effective rate of clinical treatment in the observation group was 96.67%, which was higher than 70.00% in the control group (P <0.05). Conclusion In the treatment of patients with anterior teeth displacement caused by periodontal disease, the clinical effect of orthodontic treatment combined with periodontal basic treatment is ideal. It can not only effectively improve the anterior teeth function index of patients, but also reduce the level of inflammatory factors, which is worthy of clinical application.