To analyze the application effect of health education combined with psychological nursing in patients with skin pruritus. Methods A total of 70 patients with skin pruritus admitted to Zigong First People's Hospital of from January 2022 to January 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 35 patients in each group. They were given routine nursing, health education + psychological nursing respectively. The psychological status and quality of life of the two groups were compared. Results After nursing, the scores of SAS and SDS in the observation group were lower than those in the control group, the differences were statistically significant (P <0.05). The scores of material life status, psychological function, social function and physical function in the observation group were higher than those in the control group, and the differences were statistically significant (P <0.05). Conclusion For patients with skin pruritus, health education and psychological nursing can alleviate or reduce the patient's bad psychology and improve their quality of life.