To analyze the clinical value of psychological nursing intervention for patients with plastic and aesthetic surgery during perioperative period. Methods From January 2022 to June 2023, 72 patients undergoing plastic and aesthetic surgery in our hospital were selected as the research objects. They were divided into control group and observation group by random number table method, with 36 patients in each group. The control group was given routine perioperative nursing, and the observation group was given perioperative psychological nursing intervention on the basis of the control group. The negative emotions and nursing satisfaction of the two groups were compared. Results After nursing, the scores of SAS and SDS in the observation group were lower than those in the control group, and the differences were statistically significant (P <0.05). The nursing satisfaction of the observation group was 100.00%, which was higher than 86.11% of the control group, and the difference was statistically significant (P <0.05). Conclusion For patients undergoing plastic and aesthetic surgery, perioperative psychological nursing intervention can improve their nursing satisfaction and relieve negative emotions.