To observe the clinical effect and safety of the new scheme of glycolic acid combined with CO2 fractional laser in the treatment of facial enlarged pores. Methods A total of 60 patients with facial enlarged pores admitted to theFoshan Second People's Hospital from April 2021 to August 2022 were selected as the research objects. According to the random number table method, they were divided into three groups: fractional laser group, glycolic acid group and combined group, with 20 patients in each group. The fractional laser group was treated with CO2 fractional laser, the glycolic acid group was treated with glycolic acid skin bag, and the combined group was treated with CO2 fractional laser combined with glycolic acid skin bag. The changes of pore count score and pore standard photo score of VISIA facial analyzer were compared before and 4 weeks after treatment, and the occurrence of adverse reactions was counted. Results After 4 weeks of treatment, the pore count score and pore standard photo score of VISIA facial analyzer in the three groups were lower than those before treatment, and those in the combined group was lower than that in the glycolic acid group and the fractional lasergroup, the differences were statistically significant (P <0.05). The incidence of adverse reactions in the glycolic acid group was lower than that in the combined group and the fractional laser group, and the incidence of adverse reactions in the combined group was lower than that in the fractional laser group (P <0.05). Conclusion Glycolic acid combined with CO2 fractional laser is more effective in the treatment of patients with facial enlarged pores than that in the single CO2 fractional laser treatment or glycolic acid treatment, which can improve p ores, and has higher safety.