To analyze the effect of high quality nursing service in patients with cosmetic dermatology. Methods A total of 80 patients with cosmetic dermatology admitted to our hospital from January 2021 to January 2023 were randomly divided into routine nursing group and high quality nursing group, with 40 patients in each group. The routine nursing group adopted the traditional nursing mode, and the highquality nursing group adopted the highquality nursing mode combined with highquality management. The nursing quality scores and satisfaction of the two groups were compared. Results The scores of basic nursing, ward nursing, special first-class nursing and key nursing in the highquality nursing group were higher than those in the routine nursing group, and the differences were statistically significant (P <0.05). The satisfaction of the highquality nursing group was 97.50%, which was higher than 85.00% of the routine nursing group, and the difference was statistically significant (P <0.05). Conclusion The application of highquality nursing service mode in patients with cosmetic dermatology has a better effect, which is conducive to formulating appropriate nursing measures for patients, improving the quality of nursing and patient satisfaction.