Objective To explore the effect of electromyographic biofeedback therapy on patients with central facial paralysis after stroke. Methods A total of 80 patients with central facial paralysis after stroke admitted to our hospital from January 2021 to January 2023 were selected as the research objects. They were divided into control group and experimental group by random number table method, with 40 patients in each group. The control group was treated with routine treatment, and the experimental group was treated with electromyographic biofeedback. The clinical efficacy, facial function and quality of life were compared between the two groups. Results The total effective rate of treatment in the experimental group was 85.00%, which was higher than 65.00% in the control group (P <0.05). After treatment, the FaCE score of the experimental group was higher than that of the control group (P <0.05). The SF-36 score of the experimental group was higher than that of the control group after treatment (P <0.05). Conclusion Electromyographic biofeedback therapy has a good intervention value in the treatment of central facial paralysis after stroke, which can improve the facial function, improve the therapeutic effect, and promote the quality of life of patients.