Objective To analyze the application effect of 3D technology for newborn hair transplantationin patients with cicatricial alopecia. Methods Sixty patients with cicatricial alopecia admitted to our hospital from February 2020 to February 2022 were randomly divided into control group and observation group, with 30 patients in each group. The control group was treated with conventional FUE hair transplantation, and the observation group was treated with 3D technologyfor newborn hair transplantation. The hair coverage rate, clinical efficacy, negative emotions, quality of life and surgical satisfaction were compared between the two groups. Results The hair coverage rate of the observation group was higher than that of the control group (P <0.05). The total effective rate of treatment in the observation group was 100.00%, which was higher than 86.67% in the control group (P <0.05). After treatment, the SAS score and SDS score of the observation group were lower than those of the control group (P <0.05). The scores of each dimension of SF-36 in the observation group were higher than those in the control group (P <0.05). The surgical satisfaction of the observation group was 100.00%, which was higher than 83.33% of the control group (P <0.05). Conclusion Compared with FUE hair transplantation, the effect of 3D technologyfor newborn hair transplantation in the treatment of cicatricial alopecia is more ideal, which can improve the hair coverage, reduce the negative emotions of patients, improve the satisfaction of surgery, and improve the quality of life of patients.