Objective To explore the application effect of comprehensive nursing intervention in the repair of striae gravidarum. Methods A total of 120 patients with striae gravidarum repair who were treated in our hospital from January to December 2023 were selected as the research subjects. They were divided into control group and observation group according to the random number table method, with 60 patients in each group. The control group was given routine nursing, and the observation group was given comprehensive nursing. The cognitive level of striae gravidarum, psychological resilience, improvement effect of striae gravidarum, quality of life and nursing satisfaction were compared between the two groups. Results The percentage of knowing the best treatment time, symptoms, natural prognosis and treatment methods in the observation group was higher than that in the control group (P <0.05). The scores of optimism, strength and tenacity in the observation group were higher than those in the control group (P <0.05). The average depression degree, roughness, depression volume and gray value score of the observation group after nursing were lower than those of the control group (P <0.05). The scores of physical pain, physiological function, mental health, social function, emotional function, physiological function, vitality and overall health in the observation group were higher than those in the control group (P <0.05). The nursing satisfaction of the observation group was higher than that of the control group (P <0.05). Conclusion The implementation of comprehensive nursing intervention in the repair of striae gravidarum can effectively improve the striae gravidarum, improve the patient's cognitive level and psychological elasticity of striae gravidarum, help to improve the quality of life of patients, and the patient's nursing satisfaction is high, which is worthy of clinical application.