Objective To analyze the application effect of small incision degreasing combined with continuous embedding double eyelid surgery in asymmetric double eyelid plastic surgery. Methods A total of 90 patients with asymmetric double eyelids admitted to our hospital from February 2022 to December 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 45 patients in each group. The control group was treated with double eyelid surgery, and the observation group was treated with small incision degreasing combined with continuous embedding. The clinical efficacy, surgical related indicators, treatment satisfaction, negative emotions, quality of life and complications were compared between the two groups. Results The excellent and good rate of treatment in the observation group was higher than that in the control group (P <0.05). The operation time and wound healing time of the observation group were shorter than those of the control group, and the intraoperative blood loss was less than that of the control group (P <0.05). The treatment satisfaction of the observation group was higher than that of the control group (P <0.05). After treatment, the scores of SAS and SDS in the observation group were lower than those in the control group (P <0.05). After treatment, the scores of physiological function, general health status, social function and emotional function in the observation group were higher than those in the control group (P <0.05). The incidence of complications in the observation group was lower than that in the control group (P <0.05). Conclusion Small incision degreasing combined with continuous embedding method for asymmetric double eyelid plastic surgery has better effect, higher excellent and good rate, shorter operation time, which is conducive to promoting postoperative recovery, improving patients' negative emotions, improving their quality of life and satisfaction, and the incidence of postoperative complications is low, which is worthy of clinical application.