Objective To explore the effect of holistic nursing intervention in patients with ocular defects undergoing plastic surgery for deformity. Methods A total of 70 patients with ocular defects who underwent plastic surgery for deformity in our hospital from February 2023 to February 2024 were selected as the research objects. They were divided into control group and experimental group by random number table method, with 35 patients in each group. The control group was given routine nursing, and the experimental group was given holistic nursing. The psychological mood, peri-operative period, nursing effect, quality of life and complications were compared between the two groups. Results The scores of SAS and SDS in the experimental group were lower than those in the control group (P<0.05). The hospitalization time and operation time of the experimental group were shorter than those of the control group, and the intraoperative blood loss was lower than that of the control group (P<0.05). The effective rate of nursing in the experimental group was 97.14%, which was higher than 77.14% in the control group (P<0.05). The quality of life scores of each dimension in the experimental group were higher than those in the control group (P<0.05). The incidence of complications in the experimental group was 5.71%, which was lower than 22.85% in the control group (P <0.05). Conclusion After plastic surgery for deformity in patients with ocular defects, the effect of holistic nursing intervention is better, which can improve the psychological mood and quality of life in patients, reduce the pain, and then improve their nursing satisfaction, which is worthy of clinical application.