Objective To explore the effect of systematic holistic nursing on the esthetics and masticatory function of patients with dental implants. Methods A total of 98 patients with dentition defect/loss who underwent dental implant repair in our hospital from January 2022 to January 2023 were randomly divided into observation group and control group, with 49 patients in each group. The control group was given routine nursing, and the observation group was given systematic holistic nursing. The white esthetic score (WES), pink esthetic score (PES), masticatory function score, alveolar ridge bone resorption and patient aesthetic satisfaction score were compared between the two groups. Results The total score of WES in the observation group was higher than that in the control group, and the scores of five dimensions including overall morphology of teeth, shape and volume of clinical crown, chromaticity (including hue and brightness), surface texture, translucency and characteristics were higher than those in the control group (P <0.05). The total score of PES in the observation group was higher than that in the control group, and the scores of middle gingival papilla, distal gingival papilla, labial mucosal radian, labial mucosal height, root protrusion/soft tissue color and texture in the observation group were higher than those in the control group (P <0.05). The bone resorption, implant neck and root deviation in the observation group were better than those in the control group at 6 and 12 months after operation (P <0.05). The total score of masticatory function in the observation group was higher than that in the control group, and the scores of 6 dimensions of fixed denture abnormality, influence on digestive function, stability, chewing food status, influence on food selection and edible food type were higher than those in the control group (P <0.05). The total score of aesthetic satisfaction in the observation group was higher than that in the control group, and the scores of five dimensions of dental implant aesthetics, comfort, retention, chewing and language function were higher than those in the control group (P <0.05). Conclusion Systematic holistic nursing has an important impact on the recovery of aesthetics and masticatory function of patients with dental implants, which is helpful to improve the quality of life and patients' satisfaction with dental implants.