Objective To investigate the effect of Jiedu Huayu method on wound healing and inflammatory factors in burn patients. Methods From January 2021 to January 2023, 80 burn patients admitted to our hospital were selected as the research objects. They were divided into conventional group and experimental group by random number table method, with 40 patients in each group. The conventional group was treated with silver sulfadiazine smear, the experimental group was treated with Jiedu Huayu method on the basis of the conventional group. The levels of fibroblasts, inflammatory factors and perioperative indexes were compared between the two groups. Results After treatment, the number of fibroblasts, the proportion of fibroblasts in S phase and the proportion of fibroblasts in G2/M phase in the experimental group were higher than those in the conventional group, and the proportion of fibroblasts in G1 phase was lower than that in the conventional group (P <0.05). After treatment, the levels of high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-α and brain natriuretic peptide in the experimental group were lower than those in the conventional group (P <0.05). The number of dressing changes, wound healing time, antibiotic use time and hospitalization time in the experimental group were lower than those in the conventional group (P <0.05). Conclusion Jiedu Huayu method has a significant effect on promoting wound healing in burn patients, reduce the proportion of fibroblasts in G1 phase, improve the level of inflammatory factors in patients, and improve the prognosis of patients, which is worthy of clinical applicat ion.