Objective To analyze the clinical efficacy of trehalose liquid dressing for wound repair after double eyelid surgery. Methods A total of 50 patients with double eyelid surgery were selected from October 2023 to January 2024 in Luodian Hospital of Baoshan District, Shanghai, and they were divided into study group (n =25) and control group (n =25) according to different treatment methods. The control group was treated with conventional wound external application, and the study group was treated with trehalose liquid dressing. The degree of eye swelling and pain, wound healing (wound healing time and excellent and good rate of healing), complications within 3 months after operation and adverse reactions during treatment were compared between the two groups. Results After treatment, the eye swelling score and VAS score of the study group were lower than those of the control group, and the difference were statistically significant (P <0.05). The wound healing time of the study group was (5.26±2.32)d, which was shorter than (7.87±2.63)d of the control group, and the difference was statistically significant (P <0.05). The excellent and good rate of wound healing in the study group was 92.00%, which was higher than 60.00% in the control group, the difference was statistically significant (P <0.05). The incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion Trehalose liquid dressing can reduce the degree of eyelid swelling and pain in patients after double eyelid surgery, shorten the wound healing time, effectively promote wound healing after double eyelid surgery, and reduce the incidence of complications, with higher safety.