Objective To investigate the effect of silver-containing dressing combined with recombinant bovine basic fibroblast growth factor in the treatment of deep second degree burn wounds. Methods From January 2021 to December 2022, 100 patients with deep second degree burn wounds admitted to the Department of Burns and Plastic Surgery of Handan Hangang Hospital were selected as the research objects. They were divided into control group and study group according to the random number table method, with 50 patients in each group. The control group was treated with recombinant bovine basic fibroblast growth factor, and the study group was treated with silver-containing dressing combined with recombinant bovine basic fibroblast growth factor. The levels of VEGF, clinical efficacy, pain score, scar score, pigmentation rate and inflammatory factors were compared between the two groups. Results The level of VEGF in the study group was lower than that in the control group (P <0.05). The total effective rate of treatment in the study group was 92.00%, which was higher than 78.00% in the control group (P <0.05). The pain score, scar score and pigmentation rate of the study group were lower than those of the control group (P <0.05). After treatment, IL-6 and TNF-α in the two groups were lower than those before treatment, and those in the study group were lower than those in the control group (P <0.05). Conclusion Silver-containing dressing combined with recombinant bovine basic fibroblast growth factor has a definite effect in the treatment of deep second degree burn wounds, which can improve the level of VEGF, reduce the pain of dressing change, improve the scar condition, reduce the level of inflammatory factors, and is conducive to wound recovery. It is worthy of clinical application.