Objective To investigate the effect of oral implant restoration for patients with dentition defect. Methods From February 2023 to February 2024, 98 patients with dentition defect treated in Laixi City Nanshu Central Health Center were selected and divided into reference group and study group according to random number table method, with 49 patients in each group. The reference group was treated with conventional denture restoration, and the study group was treated with oral implant restoration. The treatment effect, masticatory function and adverse reactions were compared between the two groups. Results The total effective rate of the study group was 95.92%, which was higher than 81.63% of the reference group (P <0.05). After treatment, the bite force and masticatory efficiency of the study group were higher than those of the reference group, and the occlusal balance was lower than that of the reference group (P <0.05). The incidence of adverse reactions in the study group was 2.04%, which was lower than 14.29% in the reference group (P <0.05). Conclusion In the treatment of dentition defect, oral implant restoration is effective, which can improve the masticatory function of patients and reduce adverse reactions. It is worthy of clinical application.