Objective To explore the effect of wet wound healing nursing after carbon dioxide surgery and its effect on wound healing time and scar condition. Methods A total of 60 patients who underwent carbon dioxide laser surgery in the Department of Dermatology, Zhongshan Minzhong Hospital from August 2022 to February 2024 were selected as the research objects. They were divided into control group and observation group by random number table method, with 30 patients in each group. The control group was given dry wound healing nursing, and the observation group was given wet wound healing nursing. The wound healing time, scar condition, pain degree, scar improvement effect, adverse reactions and nursing satisfaction were compared between the two groups. Results The wound healing time of the observation group was shorter than that of the control group (P <0.05). After intervention, the VSS score of the observation group was lower than that of the control group (P <0.05). The VAS score of the observation group was lower than that of the control group after intervention (P <0.05). The total effective rate of scar improvement in the observation group was 96.67%, which was higher than 80.00% in the control group (P <0.05). The incidence of adverse reactions in the observation group was 6.67%, which was lower than 30.00% in the control group (P <0.05). The nursing satisfaction of the observation group was 93.33%, which was higher than 73.33% of the control group (P <0.05). Conclusion The application of wet wound healing nursing after carbon dioxide surgery can shorten the wound healing time, reduce the scar, reduce the degree of pain, reduce the risk of adverse reactions, improve the scar improvement effect and nursing satisfaction, which is worthy of clinical application.