Objective To observe the application effect of artificial skin and growth factor in head and face burn wound repair and its influence on healing. Methods A total of 70 patients with head and face burn wound repair admitted to our hospital from April 2022 to March 2024 were selected as the research subjects. According to the different repair methods, they were divided into control group and observation group, with 35 patients in each group. The control group was treated with conventional repair, and the observation group was treated with artificial skin and growth factor on the basis of the control group. The repair effect, Dermatology Life Quality Index (DLQI), Vancouver Scar Scale (VSS), quality of life and complication rate were compared between the two groups. Results The total effective rate of repair in the observation group was 97.14%, which was higher than 71.43% in the control group (P <0.05). After repair, the scores of DLQI and VSS in the observation group were lower than those in the control group (P <0.05). The scores of all dimensions of quality of life in the observation group were higher than those in the control group (P <0.05). The incidence of complications in the observation group was lower than that in the control group (P <0.05). Conclusion In the repair of head and face burn wounds, using artificial skin and growth factor can enhance the repair effect, promote wound healing, improve scar state, alleviate its impact on the quality of life, and reduce the incidence of complications.