Objective To analyze the clinical effect and safety of different skin grafting methods in the repair of extensive burn wounds. Methods A total of 40 burn patients admitted to our hospital from June 2022 to June 2024 were selected as the research subjects. According to different repair methods, the patients were divided into stamp skin grafting group (13 patients), Meek skin grafting group (13 patients) and autologous microskin grafting group (14 patients), and stamp skin grafting, Meek skin grafting and autologous microskin grafting were used respectively. The clinical outcome, clinical indicators and complication rate were compared among the three groups. Results The wound healing rate and skin grafting survival rate of stamp skin grafting group and Meek skin grafting group were higher than those of autologous microskin grafting group, and the mortality rate was lower than that of autologous microskin grafting group, the difference were statistically significant (P <0.05). The recovery time of stamp skin grafting group and Meek skin grafting group was shorter than that of autologous microskin grafting group, and the treatment cost was lower than that of autologous microskin grafting group, the differences were statistically significant (P <0.05). The incidence of complications in the stamp skin grafting group and the Meek skin grafting group was lower than that in the autologous microskin grafting group, and the difference was statistically significant (P <0.05). Conclusion Different skin grafting methods have different effects on burn patients. Stamp skin grafting and Meek skin grafting have better clinical efficacy, shorter recovery time, lower treatment cost and higher safety.