Objective To explore the efficacy and safety of implant denture for restoration of dental defect. Methods A total of 100 patients with dental defect admitted to our hospital from January 2022 to April 2023 were selected as the research subjects, and they were divided into control group and observation group by the random number table method, with 50 patients in each group. The control group was treated with conventional fixed denture restoration, and the observation group was treated with implant denture restoration. The clinical efficacy, inflammatory factor level, oral function, quality of life, satisfaction and complications were compared between the two groups. Results The total effective rate of treatment in the observation group was 96.00%, which was higher than 76.00% in the control group (P <0.05). There was no significant difference in IL-6 level between the two groups after 3 and 7 days of intervention (P >0.05). The scores of masticatory function, fixed function, aesthetics, language function and comfort in the observation group were higher than those in the control group (P <0.05). The SF-36 score in the observation group was higher than that in the control group after intervention (P <0.05). The repair satisfaction in the observation group was 90.00%, which was higher than 60.00% in the control group (P <0.05) The incidence of complications in the observation group was lower than that in the control group (P <0.05). Conclusion Using implant denture for dental defect restoration has better therapeutic effect, which can effectively improve oral function, does not increase inflammatory fluctuations, and has higher efficacy and safety, which is beneficial to improve patients' satisfaction and quality of life after restoration.