Objective To investigate the effect of fixed appliance orthodontics combined with implanted denture restoration treatment in patients with dentition defect with malocclusion. Methods A total of 60 patients with dentition defect with malocclusion admitted to the Department of Stomatology, Xuyi People's Hospital from January 2021 to January 2023 were selected as the research subjects. They were divided into study group (n =30) and basic group (n =30) according to different treatment methods. The basic group was treated with implanted denture restoration, and the study group was treated with fixed appliance orthodontics on this basis. The treatment effect, masticatory efficiency, aesthetic degree, complications and serum index level were compared between the two groups. Results The total effective rate in the study group was 100.00%, which was higher than 83.33% in the basic group (P <0.05). After treatment, the masticatory efficiency, pink esthetic score and white esthetic score in the study group were higher than those in the basic group (P <0.05). The incidence of complications in the study group was lower than that in the basic group (P <0.05). After treatment, the levels of IL-1b, PGE, MMP-8 and sICAM-1 in the study group were lower than those in the basic group (P <0.05). Conclusion Fixed appliance orthodontics combined with implanted denture restoration treatment can improve the treatment effect of patients with dentition defect and malocclusion, improve the degree of masticatory efficiency and aesthetics, and reduce the occurrence of complications and the level of serum factors.