Objective: To explore the efficacy and safety of 595nm pulsed dye laser for rapid improvement of skin ecchymosis. Methods: 40 patients with ecchymosis admitted to the dermatology department of our hospital were prospective selected as research objects, and were divided into control group and observation group according to random number method, with 20 cases. The control group was treated with mucosinose polysulfonate cream, and the observation group was treated with 595nm pulsed dye laser. The clinical efficacy, severity score of ecchymosis and adverse reactions were compared between the two groups. Results: The total effective rate was 65.00% in the control group and 100.00% in the observation group. The total effective rate in the observation group was higher than that in the control group (χ2=8.485, P < 0.05). The ecchymosis severity scores of observation group immediately after treatment, 24h after treatment, 3d after treatment and 7d after treatment were lower than those of control group (P < 0.05). The incidence of adverse reactions in control group and observation group was 25.00% and 30.00%, respectively, with no statistical significance (P > 0.05).Conclusion: The 595nm pulsed dye laser treatment can significantly improve the clinical efficacy of patients with skin ecchymosis, improve the severity of ecchymosis, less adverse reactions, worthy of application.