Objective To explore the effect of vacuum sealing drainage technology in the repair of infected wounds. Methods From June 2022 to June 2024, 76 patients who underwent infected wound repair in the Department of Plastic and Burn Surgery, Qianxinan People's Hospital were selected as the research subjects, and they were divided into control group and experimental group by the random number table method, with 38 patients in each group. The control group was treated with conventional debridement, and the experimental group was treated with vacuum sealing drainage technology. The wound healing, inflammatory factor level and scar condition were compared between the two groups. Results The proportion of Grade A healing in the experimental group was higher than that in the control group, and the proportion of Grade B and C healing were lower than those in the control group (P <0.05). The levels of TNF-α, IL-8 and CRP in the experimental group were lower than those in the control group (P <0.05). After treatment, the scores of scar color, softness, thickness and vascular distribution in the experimental group were lower than those in the reference group (P <0.05). Conclusion The application of vacuum sealing drainage technology in the repair of infected wounds can promote wound healing, inhibit inflammatory reponse, improve scar condition and promote recovery, which is worthy of clinical application.