Objective To analyze the application effect of oral implant restoration combined with periodontal restoration in patients with dentition defect. Methods A total of 60 patients with dentition defect admitted to Yancheng Stomatological Hospital from January 2023 to May 2024 were selected, and they were divided into control group (30 patients) and observation group (30 patients) by the random number table method. The control group was given oral implant restoration alone, and the observation group was given oral implant restoration combined with periodontal restoration. The restoration effect, masticatory function (occlusal balance, occlusal force, masticatory efficiency), periodontal condition [sulcus bleeding index (BI), plaque index (PI)] were compared between the two groups. Results The total effective rate of restoration in the observation group was 96.67%, which was higher than 80.00% in the control group (P <0.05). After treatment, the masticatory efficiency and occlusal force in the observation group were higher than those in the control group, and the occlusal balance was lower than that in the control group (P <0.05). After treatment, the scores of BI and PI in the observation group were lower than those in the control group (P <0.05). Conclusion Oral implant restoration and periodontal restoration can enhance the restoration effect of patients with dentition defect, improve their periodontal condition, and promote the recovery of masticatory function, which is worthy of clinical application.