Objective To investigate the effect of cosmetic suture technique on clinical related indicators of patients with oral and maxillofacial trauma. Methods A total of 70 patients with oral and maxillofacial trauma admitted to the Department of Oral and Maxillofacial Surgery, People’s Hospital of Wuwei from November 2022 to November 2023 were selected as the research subjects, and they were divided into control group and observation group according to the different suture methods, with 35 patients in each group. The control group was operated by conventional suture technique, and the observation group was operated by cosmetic suture technique. The clinical related indicators, suture effect, complications, scar condition and satisfaction were compared between the two groups. Results The scar length, incision healing time and edema duration in the observation group were shorter than those in the control group (P <0.05). The total effective rate of suture in the observation group was 97.14%, which was higher than 77.14% in the control group (P <0.05). The scar color, texture, thickness, blood circulation and total score in the observation group were all lower than those in the control group (P <0.05). The incidence of complications in the observation group was 2.86%, which was lower than 20.00% in the control group (P <0.05). The satisfaction in the observation group was higher than that in the control group (P <0.05). Conclusion The application of cosmetic suture technique in patients with oral and maxillofacial trauma results in short scar length, fast healing and ideal suture effect, with higher aesthetic degree and patient satisfaction, which is worthy of clinical application.