Objective To investigate the effect of vacuum sealing drainage on pain level and wound infection rate in patients with burn and plastic surgery. Methods A total of 100 patients with burn and plastic surgery admitted to Yanbian University Hospital from April 2021 to March 2022 were selected as the research subjects. According to the admission order, they were divided into control group and observation group, with 50 patients in each group. The control group was treated with local drug application, and the observation group was treated with vacuum sealing drainage on the basis of the control group. The treatment effect, pain level, wound infection rate, recovery time indexes and adverse emotions were compared between the two groups. Results The excellent rate of treatment in the observation group was 96.00%, which was higher than 78.00% in the control group, and the difference was statistically significant (P <0.05). After treatment, the VAS score in the observation group was lower than that in the control group, and the difference was statistically significant (P <0.05). The incidence of wound infection in the observation group was 2.00%, which was lower than the 18.00% in the control group, and the difference was statistically significant (P <0.05). The wound healing time and skin blood circulation recovery time in the observation group were shorter than those in the control group, and the differences were statistically significant (P <0.05). The HAMD score in the observation group was lower than that in the control group, and the difference was statistically significant (P <0.05). Conclusion The application of vacuum sealing drainage in patients with burn and plastic surgery can effectively reduce the degree of pain and the incidence of infection, which is conducive to improving the treatment effect, alleviating patients’ adverse emotions, and promoting recovery.