Objective To investigate the effect of absorbable suture on incision healing after infusion port implantation. Methods A total of 80 patients who underwent infusion port implantation admitted to Dongming People’ s Hospital from January 2021 to January 2024 were selected, and they were divided into control group and observation group by the random number table method, with 40 patients in each group. The control group was treated with traditional silk suture, and the observation group was treated with absorbable suture. The clinical indexes, incision healing and incision-related complications were compared between the two groups. Results There was no significant differences in operation time and postoperative temperature between the two groups (P >0.05). The incision healing time of the observation group was shorter than that of the control group (P <0.05). The primary incision healing rate of the observation group was higher than that of the control group, and the secondary incision healing rate of the observation group was lower than that of the control group (P <0.05), and there was no significant difference in the tertiary incision healing rate between the two groups (P >0.05). The incidence of incision-related complications was lower than that of the control group (P <0.05). Conclusion For patients with infusion port implantation, the application of absorbable suture is helpful to improve the quality of incision healing and reduce incision-related the complications.