Objective To explore the application effect of dermatovenereology typical case graphics library in the teaching of general practitioner standardization training. Methods A total of 80 general practitioners who underwent standardization training in our hospital from January 2022 to August 2023 were selected as the research subjects, and they were randomly divided into control group and observation group, with 40 general practitioners in each group. The control group was given traditional teaching mode, and the observation group was given dermatovenereology typical case graphics library to assist the teaching on the basis of the control group. The discharge examination results and teaching evaluation results were compared between the two groups. Results The theory examination, diagnosis of disease by pictures and total examination score in the observation group were all better than those in the control group, and the differences were statistically significant (P <0.05). There was no significant difference in doctor-patient communication score between the two groups (P >0.05). The proportion of recognition of teaching methods, learning efficiency improvement, learning motivation improvement, clinical diagnosis accuracy improvement and combination of basic theory and clinical improvement in the observation group were higher than those in the control group, and the differences were statistically significant (P <0.05). Conclusion The application of the dermatovenereology typical case graphics library in the teaching of general practitioner standardization training can improve the teaching quality and efficiency, which is conducive to improving the discharge examination scores and teaching evaluation results. The application value is exact.