Objective To explore the effect of informatization continuous nursing mode based on goal attainment theory on treatment compliance and self-management ability of patients with psoriasis. Methods A total of 88 patients with psoriasis admitted to our hospital from January 2023 to June 2024 were selected as the research subjects, and they were divided into conventional group and exploration group according to the different nursing modes, with 44 patients in each group. The conventional group was given conventional nursing mode, and the exploration group was given informatization continuous nursing mode based on goal attainment theory. The skin lesion degree, treatment compliance, self-management ability, quality of life and nursing satisfaction were compared between the two groups. Results The score of skin lesion degree in the exploration group after nursing was lower than that in the conventional group (P <0.05). The score of treatment compliance in the exploration group after nursing was higher than that in the conventional group (P <0.05). The score of self-management ability in the exploration group after nursing was higher than that in the conventional group (P <0.05). The scores of quality of life in the exploration group were lower than those in the conventional group (P <0.05). The nursing satisfaction in the exploration group was 100.00%, which was higher than 86.36% in the conventional group (P <0.05). Conclusion The application of informatization continuous nursing mode based on goal attainment theory in patients with psoriasis is accurate, which can not only effectively improve patients’ skin lesions and quality of life, but also enhance their treatment compliance and self-management ability. Meanwhile, patients are more satisfied with nursing service, which is worthy of clinical application.