Objective: To investigate the application effect of orthodontic treatment on tooth function and aesthetics in patients with anterior tooth displacement caused by periodontal disease. Methods: 108 patients with anterior tooth displacement caused by periodontal disease who received treatment at our hospital from March 2022 to March 2025 were divided into two groups. There were 54 cases in an observation group and 54 cases in a control group. The control group received conventional treatment, and the observation group received orthodontic treatment. After treatment, the periodontal indicators (periodontal pocket depth, anterior tooth coverage, alveolar bone height, probing bleeding rate), functional improvement/aesthetic score (chewing, swallowing, oral expression, teeth alignment), quality of life score (social function, physiological function, material function, psychological function), serum cytokine levels (TNF - α, IL-2, IL-6), and incidence of adverse reactions (bad breath, periodontal abscess, pain, tooth loosening) were compared between the two groups of patients. After treatment, the periodontal indicators of the observation group were better than those of the control group, and the functional improvement/aesthetic score and quality of life score were higher than those of the control group. The serum cytokine levels were stable in the control group, and the incidence of adverse reactions was less than the control group. The data difference was statistically significant (P<0.05). Conclusion: Orthodontic treatment for patients with anterior tooth displacement caused by periodontal disease can effectively improve their dental function, promote their dental aesthetics, and reduce the occurrence of adverse reactions.