Objective To analyze the effect of flurbinprofen axetil combined with dezocine in preemptive multimodal analgesia during nasal augmentation with costal cartilage. Methods A total of 68 patients undergoing nasal augmentation with costal cartilage admitted to Shanghai Electric Power Hospital from January 2023 to January 2024 were selected as the research subjects. According to the random number table method, they were divided into control group and experimental group, with 34 patients in each group. The control group was given conventional analgesics alone, and the experimental group was given flurbinprofen axetil combined with dezocine. The extubation time, consciousness recovery time, agitation, pain and the percentage of demand for analgesics remedy were compared between the two groups. Results The extubation time and consciousness recovery time in the experimental group were shorter than those in the control group (P <0.05). The scores of SAS and NRS in the experimental group at each time point were lower than those in the control group (P <0.05). The percentage of demand for analgesics remedy in the experimental group was lower than that in the control group (P <0.05). Conclusion Flurbinprofen axetil combined with dezocine is effective in preemptive multimodal analgesia after nasal augmentation with costal cartilage, which can shorten the time of extubation and consciousness recovery, reduce the degree of pain, and decrease the administration of postoperative analgesics.